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black nike free run 2 , Using the available evidence, Naphthol AS BR isn't considered likely to end up mutagenic.
The boldness within the health link between TDBPD, TDBD and Naphthol AS BR is less than that for other dyes in such a assessment, because the characterization was based mainly on model results.
Benzidine Derivatives: TODI and 4N TMBTODI (CAS RN 91 97 4).
Within a mutagenicity study in bacteria, TODI was discovered to be mutagenic in Salmonella typhimurium strains TA98 and TA1538 within the presence, yet not within the absence, of metabolic activation.
This Benzidine Derivative was negative in Salmonella typhimurium strains TA100, TA1535 and TA1537 and Escherichia coli WP2uvrA, with or without metabolic activation.
From the same study, TODI induced chromosomal aberrations in Chinese hamster lung cells within the presence, yet not within the absence, of metabolic activation (JETOC 1996).
In unpublished reports identified as submissions to REACH within the EU, TODI was positive for gene mutation in mammalian cells within the presence, yet not within the absence, of metabolic activation.
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